The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Catalytic activity of acids. Evaluation of the activities of the hydrogen ion and the undissociated acid》. Authors are Dawson, H. M.; Powis, F..The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Quality Control of 2,3-Dibromopropionic acid. Through the article, more information about this compound (cas:600-05-5) is conveyed.
The catalytic activities of HCl, CCl2CO2H, CHClCOOH, α,β-dibromopropionic acid and HOAc on the velocity of the keto-enol transformation of acetone have been measured. The results obtained were entirely at variance with the theory that the catalyzing activity of an acid is determined by its H-ion concentrate, but were in good agreement with the view that both non-ionized mols. and ions take part in the acceleration, the actual catalytic effect being additively composed of the effects due to the two components. The activity of the non-ionized acid diminishes rapidly as its tendency to ionize decreases, as is shown by the numbers which express the activities of the mols. in terms of that of H+ ion: HCl, 1.77; CCl2CO2H, 0.50; α,β-dibromopropionic acid, 0.152; CHClCO2H, 0.056; HOAc, 0.0034. It does not seem possible to say whether these ratios are independent of the nature of the reaction catalyzed.
《Catalytic activity of acids. Evaluation of the activities of the hydrogen ion and the undissociated acid》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)Quality Control of 2,3-Dibromopropionic acid.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem