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The aim of the study was to develop a self-emulsifying drug delivery systems (SEDDS) comprising chlorhexidine (CX) and monododecylamide-EDTA (alkyl-EDTA) exhibiting enhanced microbicidal properties. SEDDS containing 20% Captex 300, 45% Cremophor EL, 17% Tween 80 and 18% DMSO were loaded with 3% (m/v) alkyl-EDTA (FA) and formulations of 1% CX and 1.5% (m/v) alkyl-EDTA (FA-CX1% and FA-ED1.5%) were prepared separately as well as in combination (FA-CX1%ED1.5%). Resazurin assay was performed to assess the biocompatibility of SEDDS in concentrations of 0.5% and 1%. Alkyl-EDTA SEDDS were also evaluated for their binding affinity towards Ca2+ and Mg2+ as well as for augmented antimicrobial properties using E. coli as model germ. Biocompatibility assay of SEDDS revealed that >85% of cells remained viable after 4 h. SEDDS FA efficiently bound 770 ± 19 mumol/g of calcium and 784 ± 16 mumol/g of magnesium, respectively. SEDDS FA-CX1%ED1.5% showed a 34.3- and 12.9-fold enhanced antimicrobial effect compared to FA-ED1.5% and FA-CX1%, respectively. The combination of CX with alkyl-EDTA in SEDDS seems therefore to be a promising strategy to enhance the antimicrobial activity of this antiseptic drug.
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H14844N – PubChem