Chemistry is an experimental science, Product Details of 29976-53-2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 29976-53-2, Name is N-Carbethoxy-4-piperidone
Degeneration of the hippocampus is associated with Alzheimer’s disease and occurs very early in the progression of the disease. Current options for treating the cognitive symptoms associated with Alzheimer’s are inadequate, giving urgency to the search for novel therapeutic strategies. Pharmacologic agents that safely enhance hippocampal neurogenesis may provide new therapeutic approaches. We discovered the first synthetic molecule, named P7C3, which protects newborn neurons from apopotic cell death, and thus promotes neurogenesis in mice and rats in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals. We describe the results of a medicinal chemistry campaign to optimize the potency, toxicity profile, and stability of P7C3. Systematic variation of nearly every position of the lead compound revealed elements conducive toward increases in activity and regions subject to modification. We have discovered compounds that are orally available, nontoxic, stable in mice, rats, and cell culture, and capable of penetrating the blood-brain barrier. The most potent compounds are active at nanomolar concentrations. Finally, we have identified derivatives that may facilitate mode-of-action studies through affinity chromatography or photo-cross-linking.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 29976-53-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 29976-53-2, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H10105N – PubChem