In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2008-75-5, name is 1-(2-Chloroethyl)piperidine hydrochloride, introducing its new discovery. HPLC of Formula: C7H15Cl2N
We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2?-dichloro-3,3?-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines. The pentacyclic diquinothiazine ring systems were identified as diquino[3,2-b;3?,4?-e][1,4]thiazine, diquino[3,2-b;5?,6?-e][1,4]thiazine, diquino[3,2-b;6?,5?-e][1,4]thiazine and diquino[3,2-b;8?,7?-e][1,4]thiazine with advanced two-dimensional 1H and 13C NMR techniques (COSY, ROESY, HSQC and HMBC) of N-methyl derivatives. The identification of pentacyclic ring system was confirmed by X-ray diffraction analysis of selected N-alkyl derivatives. The X-ray analysis revealed different spatial structures of the ring system (planar and folded). NH-diquinothiazines were further transformed into N-alkyl and N-dialkylaminoalkyl derivatives. Most of diquinothiazines exhibited significant cancer cell growth inhibition against the human glioblastoma SNB-19, colorectal carcinoma Caco-2, breast cancer MDA-MB-231 and lung cancer A549 cell lines with the IC50 values < 3 muM. This anti-proliferative activity was found to be more than for cisplatin. The most promising compound, 7-dimethylaminopropyldiquino[3,2-b;6?,5?-e]thiazine, was used for gene expression analysis by reverse transcription?quantitative real-time PCR (RT?QPCR) method. The expression of H3, TP53, CDKN1A, BCL-2 and BAX genes revealed that this compound inhibited the proliferation in all cells (H3) and activated mitochondrial events of apoptosis (BAX/BCL-2) in two cancer cell lines (SNB-19 and Caco-2). The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2008-75-5 is helpful to your research. HPLC of Formula: C7H15Cl2N
Reference：
Piperidine – Wikipedia,
Piperidine | C5H10952N – PubChem