Synthetic Route of 189442-87-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 189442-87-3, Name is Ethyl N-Boc-4-methylpiperidine-4-carboxylate, molecular formula is C14H25NO4. In a Article£¬once mentioned of 189442-87-3
Synthesis and SAR of Imidazo[1,5-a[pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disease which has a higher prevalence and incidence in older people. The need for improved AD therapies is unmet. The 5-hydroxytryptamine4 receptor (5-HT4R) partial agonists may be of benefit for both the symptomatic and disease-modifying treatment of cognitive disorders associated with AD. Herein, we report the design, synthesis and SAR of imidazo[1,5-a] pyridine derivatives as 5-HT4R partial agonists. The focused SAR, optimization of ADME properties resulted the discovery of compound 5a as potent, selective, brain penetrant 5-HT4 partial agonist as a lead compound with good ADME properties and efficacy in both symptomatic and disease modifying animal models of cognition.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 189442-87-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 189442-87-3, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H21905N – PubChem