Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 144222-22-0, is researched, SMILESS is NCC1CCN(C(OC(C)(C)C)=O)CC1, Molecular C11H22N2O2Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of the American Chemical Society called Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease, Author is Yao, Yuan; Huo, Tong; Lin, Yi-Lun; Nie, Shenyou; Wu, Fangrui; Hua, Yuanda; Wu, Jingyu; Kneubehl, Alexander R.; Vogt, Megan B.; Rico-Hesse, Rebecca; Song, Yongcheng, the main research direction is piperidin pyrazin synthesis antiviral NS2B NS3 protease Flavivirus infection.Application of 144222-22-0.
Flaviviruses, including dengue, West Nile and recently emerged Zika virus, are important human pathogens, but there are no drugs to prevent or treat these viral infections. The highly conserved Flavivirus NS2B-NS3 protease is essential for viral replication and therefore a drug target. Compound screening followed by medicinal chem. yielded a series of drug-like, broadly active inhibitors of Flavivirus proteases with IC50 as low as 120 nM. The inhibitor exhibited significant antiviral activities in cells (EC68: 300-600 nM) and in a mouse model of Zika virus infection. X-ray studies reveal that the inhibitors bind to an allosteric, mostly hydrophobic pocket of dengue NS3 and hold the protease in an open, catalytically inactive conformation. The inhibitors and their binding structures would be useful for rational drug development targeting Zika, dengue and other Flaviviruses.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem