A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: C11H19NO3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 118156-93-7, Name is tert-Butyl 3-formylpiperidine-1-carboxylate, molecular formula is C11H19NO3. In a Article, authors is Aguilar, Angelo£¬once mentioned of 118156-93-7
Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction
Inhibition of the menin-mixed lineage leukemia (MLL) protein-protein interaction is a promising new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein our structure-based design, synthesis, and evaluation of a new class of small-molecule inhibitors of the menin-MLL interaction (hereafter called menin inhibitors). Our efforts have resulted in the discovery of highly potent menin inhibitors, as exemplified by compound 42 (M-89). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion. The determination of a co-crystal structure of M-89 in a complex with menin provides the structural basis for their high-affinity interaction. Further optimization of M-89 may lead to a new class of therapy for the treatment of MLL leukemia.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 118156-93-7, help many people in the next few years.HPLC of Formula: C11H19NO3
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H16592N – PubChem