Awesome and Easy Science Experiments about tert-Butyl 4-formylpiperidine-1-carboxylate

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A new tetrahydropyranone synthesis has been developed that leads to cis-2,6-disubstituted 3,3-dimethyltetrahydropyran-4-one rings by condensation of an aldehyde and a hydroxy silyl enol ether. The reaction works with a variety of aldehydes to produce the tetrahydropyranone products in moderate to high yields. This new method was applied to the enantioselective synthesis of cyanolide A and its aglycone.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H16495N – PubChem