Chemistry is an experimental science, Quality Control of: N,N-Dimethylpiperidin-4-amine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 50533-97-6, Name is N,N-Dimethylpiperidin-4-amine
Cyclin D dependent kinases (CDK4 and CDK6) regulate entry into S phase of the cell cycle and are validated targets for anticancer drug discovery. Herein we detail the discovery of a novel series of 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivatives as highly potent and selective inhibitors of CDK4 and CDK6. Medicinal chemistry optimization resulted in 83, an orally bioavailable inhibitor molecule with remarkable selectivity. Repeated oral administration of 83 caused marked inhibition of tumor growth in MV4-11 acute myeloid leukemia mouse xenografts without having a negative effect on body weight and showing any sign of clinical toxicity. The data merit 83 as a clinical development candidate.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of: N,N-Dimethylpiperidin-4-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50533-97-6, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H3934N – PubChem