Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, molecular formula is , belongs to piperidines compound. In a document, author is Kumar, Raju Suresh, Application In Synthesis of 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione.
Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-alpha and nitrite inhibition
Stereoselective synthesis of a small library of novel spiroheterocyclic hybrids including indolizine, oxindole, and substituted piperidine units has been accomplished in [bmim]Br using a [3 + 2]cyclo-addition strategy in good yield and were tested for their anti-inflammatory activities. The effects of compounds (4a-o) against inflammation were studied using carrageenan-induced hind paw oedema, croton oil-induced ear oedema, and cotton pellet-induced granuloma models. Among the heterocyclic hybrids, compounds 4d, 4g, and 4o showed significant anti-inflammatory activities against acute and chronic inflammatory models. These compounds also showed significant inhibition of PGE2, TNF-alpha, and nitrite levels in carrageenan-induced hind paw oedema. Thus it is evident from our study that these novel spiroheterocyclic hybrids 4d, 4g, and 4o displayed significant anti-inflammatory effects that involve the reduction of PGE(2), TNF-alpha, and nitrite levels. (C) 2018 Elsevier Masson SAS. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 827026-45-9, in my other articles. Application In Synthesis of 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem