Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Science & Technology – Other Topics very interesting. Saw the article Copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones for synthesis of polysubstituted anilines published in 2019, Reprint Addresses Su, WP (corresponding author), ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China.; Su, WP (corresponding author), Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.
Metal-catalyzed beta-C-H functionalization of saturated carbonyls via dehydrogenative desaturation proved to be a powerful tool for simplifying synthesis of valuable beta-substituted carbonyls. Here, we report a copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones that initiates the three-component coupling of saturated ketones, amines and N-substituted maleimides to construct polysubstituted anilines. The protocol presented herein enables both linear and alpha-branched butanones to couple a wide spectrum of amines and various N-substituted maleimides to produce diverse tetra- or penta-substituted anilines in fair-to-excellent yields with good functional group tolerance. The mechanism studies support that this ketone dehydrogenative gamma-C(sp(3))-H amination was triggered by the ketone alpha,beta-dehydrogenation desaturation that activates the adjacent gamma-C(sp(3))-H bond towards functionalization. This alpha,beta-dehydrogenation desaturation-triggered cascade sequence opens up a new avenue to the remote C(sp(3))-H functionalization of saturated ketones and has the potential to enable the rapid syntheses of complex compounds from simple starting materials.
About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
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