Recommanded Product: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Synthesis and Evaluation of (1S,2R/1R,2S)-Aminocyclohexylglycyl PNAs as Conformationally Preorganized PNA Analogues for DNA/RNA Recognition. Author is Govindaraju, T.; Kumar, Vaijayanti A.; Ganesh, Krishna N..
Conformationally constrained cis-aminocyclohexylglycyl PNAs (peptide nucleic acids) have been designed on the basis of stereospecific imposition of 1,2-cis-cyclohexyl moieties on the aminoethyl segment of aminoethylglycyl PNA (aegPNA). The introduction of the cis-cyclohexyl ring may allow the restriction of the torsion angle β in the ethylenediamine segment to 60-70° that is prevalent in PNA2:DNA and PNA:RNA complexes. The synthesis of the optically pure monomers, thyminyl derivatives (1S,2R)-I and (1R,2S)-II, is achieved by stereoselective enzymic hydrolysis of an intermediate ester, trans-2-azidocyclohexyl butanoate. The chiral PNA oligomers were synthesized with I and II in the center and N-terminus of aegPNA. Differential gel shift retardation with one or more units of modified monomer units was observed as a result of hybridization of PNA sequences with complementary DNA sequences. Hybridization studies with complementary DNA and RNA sequences using UV-Tm measurements indicate that PNA with (1S,2R)-cyclohexyl stereochem. enhances selective binding with RNA over DNA as compared to control aegPNA and PNA with the other (1R,2S) isomer.
There is still a lot of research devoted to this compound(SMILES：O=C(OC(C)(C)C)N[C@@H]1[C@@H](O)CCCC1)Recommanded Product: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, and with the development of science, more effects of this compound(145166-06-9) can be discovered.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem