Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 13925-03-6, Name is 2-Ethyl-6-methylpyrazine, SMILES is CC1=CN=CC(CC)=N1, in an article , author is Qi, Chenxiao, once mentioned of 13925-03-6, HPLC of Formula: C7H10N2.
Hexafluoroisopropanol-Promoted Haloamidation and Halolactonization of Unactivated Alkenes
Pyrrolidine and piperidine derivatives bearing halide functional groups are prevalent building blocks in drug discovery as halides can serve as an anchor for post-modifications. In principle, one of the simplest ways to build these frameworks is the haloamination of alkenes. While progress has been made in this field, notably with the development of enantioselective versions, this reaction is still fraught with limitations in terms of reactivity. Besides, a major question remaining is to understand the mechanism at work. The formation of a haliranium intermediate is typically mentioned, but limited mechanistic evidence supports it. Reported here is an efficient metal- and oxidant-free protocol to achieve the haloamidation of olefins, promoted by hexafluoroisopropanol, along with a DFT investigation of the mechanism. These findings should guide the future development of more complex transformations in the field of halofunctionalization.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 13925-03-6, you can contact me at any time and look forward to more communication. HPLC of Formula: C7H10N2.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem