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Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically activemolecules. Metal-catalyzed cross-couplings between halogenoN-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem