Related Products of 26905-02-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 26905-02-2, Name is 4-(4-Chlorophenyl)piperidine, molecular formula is C11H14ClN. In a Article，once mentioned of 26905-02-2
Dual-acting compounds that combine H3 antagonism with anticholinesterase properties are currently emerging as a novel and promising therapeutic approach in the treatment of multi-factorial disorders primarily characterized by cholinergic deficits such as Alzheimer’s disease. A series of novel nonimidazole H3 ligands was developed from the chemical manipulation of 1,1?-octa-, -nona-, and -decamethylene-bis-piperidines – H3 antagonists that had been the subject of previous investigations. These compounds were evaluated for in vitro binding affinity, antagonistic potency, and selectivity at rodent and human histamine H3 receptors, inhibitory activity at rat brain cholinesterase, and in vivo CNS access and cholinomimetic effects. Within the present series, the tetrahydroaminoacridine hybrid 18 stands out as one of the most attractive molecules, synergistically combining nanomolar and selective H3 antagonism with remarkable anticholinesterase activity. From this original starting point, it is hoped that future investigations will lead to dual-acting compounds that can selectively enhance central cholinergic neurotransmission and thus facilitate the treatment of cognitive disorders.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 26905-02-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 26905-02-2, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H12940N – PubChem