Authors Okumus, A; Elmas, G; Kilic, Z; Binici, A; Ramazanoglu, N; Acik, L; Cosut, B; Hokelek, T; Guzel, R; Tunali, BC; Turk, M; Simsek, H in WILEY published article about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; INTERMOLECULAR INTERACTIONS; BIOLOGICAL-ACTIVITIES; CRYSTAL-STRUCTURES; CHIRAL CONFIGURATIONS; QUANTITATIVE-ANALYSIS; HIRSHFELD SURFACES; CYCLOTRIPHOSPHAZENE; ANTITUBERCULOSIS in [Okumus, Aytug; Elmas, Gamze; Kilic, Zeynel] Ankara Univ, Dept Chem, Ankara, Turkey; [Binici, Arzu] Republ Turkey Minist Hlth, Ankara, Turkey; [Ramazanoglu, Nagehan] Sci & Technol Res Council Turkey, Ankara, Turkey; [Acik, Leyla] Gazi Univ, Dept Biol, Ankara, Turkey; [cosut, Bunyemin] Gebze Tech Univ, Dept Chem, Gebze, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, Ankara, Turkey; [Guzel, Remziye] Dicle Univ, Dept Chem, Diyarbakir, Turkey; [Tunali, Beste cagdas; Turk, Mustafa] Kirikkale Univ, Dept Bioengn, Kirikkale, Turkey; [Simsek, Hulya] Bozok Univ, Dept Microbiol, Yozgat, Turkey in 2021, Cited 106. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7
In this study, two kinds of compounds, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes, were obtained by the Cl replacement reaction of N4P4Cl8 (1) with an equimolar amount of sodium 3-(N-ferrocenylmethylamino)-1-propanoxide (2). The reactions of 2,4-ansa (3) with excess diamines and dialkoxides resulted in the formation of ansa-cyclotetraphosphazenes (3a-3e). Spiro (4) was reacted with excess diamines and dialkoxides to give the mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d). Although 2,4-ansa (3) produced the dispiro (3a) with N-(4-fluorobenzyl)-N ‘-methylethane-1,2-diamine, it afforded both monospiro (3b) and dispiro (3c) with N-(4-fluorobenzyl)-N ‘-methylpropane-1,3-diamine. However, spiro (4) yielded a trispiro (4a) with N-(4-fluorobenzyl)-N ‘-methylethane-1,2-diamine and 2,6-dispiro (4b) with N-(4-fluorobenzyl)-N ‘-methylpropane-1,3-diamine. The structures of the phosphazenes were elucidated by FTIR, ESI-MS and/or HRMS, spectroscopic and crystallographic (for 3f and 4b) data. Furthermore, the electrochemical findings of cyclotetraphosphazenes exhibited electrochemically reversible one-electron oxidation of Fe-redox centre. As an example, the chirality of 3c was investigated by P-31 NMR spectroscopy on the addition of (R)-(+)-2,2,2-trifluoro-1-(9 ‘-anthryl)-ethanol, chiral solvating agent (CSA). The circular dichroism (CD) (for 3d and 3e), HPLC (for 3d, 3e and 3f) and X-ray (for 3f) display that these compounds have chirality (RS ‘ or SR ‘) in the solution and solid state. This paper also focuses on the antimicrobial activities, the interactions with pBR322 DNA, in vitro anticancer activity against L929 fibroblast and MCF7 breast cells, and antituberculosis activity against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.
Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Okumus, A; Elmas, G; Kilic, Z; Binici, A; Ramazanoglu, N; Acik, L; Cosut, B; Hokelek, T; Guzel, R; Tunali, BC; Turk, M; Simsek, H or send Email.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem