Synthetic Route of 1722-95-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1722-95-8, Name is (R)-2-Methylpiperidine, molecular formula is C6H13N. In a Article，once mentioned of 1722-95-8
This letter describes the synthesis and structure activity relationship (SAR) studies of structurally novel M4 antagonists, based on a 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazine core, identified from a high-throughput screening campaign. A multi-dimensional optimization effort enhanced potency at human M4 (hM4 IC50s < 200 nM), with only moderate species differences noted, and with enantioselective inhibition. Moreover, CNS penetration proved attractive for this series (rat brain:plasma Kp = 2.1, Kp,uu = 1.1). Despite the absence of the prototypical mAChR antagonist basic or quaternary amine moiety, this series displayed pan-muscarinic antagonist activity across M1-5 (with 9- to 16-fold functional selectivity at best). This series further expands the chemical diversity of mAChR antagonists. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 1722-95-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1722-95-8, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H469N – PubChem