146667-84-7, Name is tert-Butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate, belongs to piperidines compound, is a common compound. 146667-84-7. In an article, authors is Akwabi-Ameyaw, Adwoa, once mentioned the new application about 146667-84-7.
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severity of cholestasis in the ANIT acute cholestatic rat model.
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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18597N – PubChem