Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Chemistry very interesting. Saw the article Modular Continuous Flow Synthesis of Imatinib and Analogues published in 2019, Reprint Addresses Jamison, TF (corresponding author), MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.
A modular continuous flow synthesis of imatinib and analogues is reported. Structural y diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.
Welcome to talk about 177-11-7, If you have any questions, you can contact Fu, WC; Jamison, TF or send Email.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem