Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ name: 1-Oxa-3,8-diazaspiro[4.5]decan-2-one, Which mentioned a new discovery about 5052-95-9
Two novel series of spirocyclic piperidine analogs appended to a pyrazolo[1,5-a]pyridine core were designed, synthesized and evaluated for their anti-HCV activity. A series of piperidine ketals afforded dispiro 6p which showed excellent in vitro anti-HCV activities (EC50 of 1.5 nM and 1.2 nM against genotype 1a and 1b replicons, respectively). A series of piperidine oxazolidinones afforded 27c which showed EC50’s of 10.9 nM and 6.1 nM against 1a and 1b replicons, respectively. Both compounds 6p and 27c bound directly to non-structural NS4B protein in vitro (IC50’s = 10.2 and 30.4 nM, respectively) and exhibited reduced potency in replicons containing resistance mutations encoding changes in the NS4B protein.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, name: 1-Oxa-3,8-diazaspiro[4.5]decan-2-one, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5052-95-9
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H8540N – PubChem