Andres, Jose-Ignacio et al. published their research in Journal of Medicinal Chemistry in 2012 | CAS: 58333-75-8

4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Quality Control of 4-(2-Methoxyphenyl)piperidine

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging was written by Andres, Jose-Ignacio;Alcazar, Jesus;Cid, Jose Maria;De Angelis, Meri;Iturrino, Laura;Langlois, Xavier;Lavreysen, Hilde;Trabanco, Andres A.;Celen, Sofie;Bormans, Guy. And the article was included in Journal of Medicinal Chemistry in 2012.Quality Control of 4-(2-Methoxyphenyl)piperidine This article mentions the following:

Arylpiperidinyl triazolo[4,3-a]pyridines such as I (R = 11CH3; R1, R2, R3, R4 = H, F; R5 = Cl, F3C) were prepared as positron emission tomog. (PET) radiotracers for in vivo imaging of the allosteric binding site of the metabotropic glutamate (mGlu) receptor subtype 2 (mGluR2). I (R = Me; R1, R2, R3, R4 = H, F; R5 = Cl, F3C) were potent and selective pos. allosteric modulators (PAMs) of the mGlu receptor 2 (mGluR2) in a [35S]GTPγS binding assay and were able to displace a previously developed mGluR2 PAM radioligand with IC50 values in the low nanomolar range. The brain uptake of I (R = 11CH3; R1, R2, R3, R4 = H, F; R5 = Cl, F3C) in normal rats was determined; the fractions of intact tracer and of polar metabolites in rat cerebrum and cerebellum for I (R = 11CH3; R1, R2, R3, R4 = H, F; R5 = Cl) were determined Preliminary small-animal PET (μPET) studies in rats indicated that I (R = 11CH3; R1 = R4 = F; R2 = R3 = H; R5 = Cl) bound specifically and reversibly to an mGluR2 allosteric site, making it a promising candidate for PET imaging of mGluR2 in the brain. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Quality Control of 4-(2-Methoxyphenyl)piperidine).

4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Quality Control of 4-(2-Methoxyphenyl)piperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem