Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4 was written by Andonova, Lily;Zheleva-Dimitrova, Dimitrina;Georgieva, Maya;Zlatkov, Alexander. And the article was included in Biotechnology & Biotechnological Equipment in 2014.Recommanded Product: 27469-60-9 This article mentions the following:
Six new aryl/aralkyl substituted piperazine derivatives, containing methylxanthine moiety I (R = Bn, 4-FC6H4, 4-HOC6H4, etc.) were synthesized. All compounds were in vitro screened for their activity as antioxidants using DPPH (2,2′-Diphenyl-1-picrylhydrazyl), ABTS (2,2′-azinobis-(3-ethylbenzothiazine-6-sulfonic acid)) and FRAP (ferric reducing/antioxidant power) methods. The antioxidant activity of the studied compounds against lipid peroxidation was also measured. The highest antioxidant activity was demonstrated by compound I (R = 4-HOC6H4). It is obvious that the presence of a hydroxyl group in the structure is essential for the antioxidant properties and should be taken into consideration in further design of structures with potential antioxidant properties. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Recommanded Product: 27469-60-9).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Recommanded Product: 27469-60-9
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics