Synthesis of novel 1,3-thiazin-4-ones by acetylene diester cyclization and their anticancer activities was written by Anand, Selvam Athavan Alias;Loganathan, Chandrasekaran;Thomas, Nisha Susan;Saravanan, Kuppusamy;Alphonsa, Antony Therasa;Kabilan, Senthamaraikannan. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2016.Product Details of 33439-27-9 This article mentions the following:
A novel series of 1,3-thiazin-4-one derivatives containing a piperidyl ring I (R1 = Ts, Boc; R2 = H, Me; R3 = Me, Et), II (R1 = Boc; R2 = H, Me) were designed and synthesized efficiently by thioamide and acetylene diester cyclization reaction via aminolysis of the ester group and the elimination of an alc. mol. All the newly synthesized compounds were studied for their in vitro anticancer activity against human liver cancer cell lines Hep G2 using MTT assay. The IC50 values of the tested compounds ranged between 7.48 +/- 0.71 and 56.57 +/- 1.37 μM. Further, the apoptosis evaluation by the mitochondrial membrane potential using JC-1 dye was carried out and the results are in good agreement with the cytotoxicity studies. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Product Details of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem