With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923009-50-1,tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate,as a common compound, the synthetic route is as follows.
923009-50-1, Preparation 45: tert-butyl 2-[bis(4-fluorophenyl)methyl]-1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P45)To a solution of ferf-butyl l-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (p44, 150 mg, 0.589 mmol) in dry DM F (2 mL) was added NaH (60 % dispersion in mineral oil, 28.27 mg, 0.7 mmol) followed by addition of l-[chloro(4-fluorophenyl)methyl]-4-fluorobenzene (0.121 m L, 0.648 mmol). The mixture was heated at 100 C overnight, then cooled down to RT and the solvent was removed under vacuum. The residue was dissolved in ethyl acetate and washed with water. Organic phase was dried and concentrated under reduced pressure. Crude material was purified by FC on silica gel (eluent: Cy to Cy/EA to 70/30) affording ferf-butyl 2-[bis(4-fluorophenyl)methyl]-l-oxo-2,7-diazaspiro[4.5]decane-7- carboxylate (p45, 80 mg, y= 30%) as white solid.MS (ES) (m/z): 457.2 [M+H]+.
As the paragraph descriping shows that 923009-50-1 is playing an increasingly important role.
Reference：
Patent; SHIRE INTERNATIONAL GMBH; SEMERARO, Teresa; TARSI, Luca; MICHELI, Fabrizio; LUKER, Tim; CREMONESI, Susanna; (122 pag.)WO2016/42451; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem