With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-48-6,tert-Butyl 4-carbamoylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
91419-48-6, To a solution of tert-butyl 4-carbamoylpiperidine-1-carboxylate (160 mg, 0.7 mmol) in DCM (2 mL) was added a HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min and concentrated to give the title compound as a white solid (112 mg, 97) .1H NMR (400 MHz, CD3OD) : delta ppm 3.33-3.39 (m, 2H) , 2.95-3.24 (m, 2H) , 2.50-2.58 (m, 1H) , 1.95-1.99 (m, 2H) , 1.76-1.87 (m, 2H) and MS-ESI: m/z 129.20 [M+H-HCl] +.
As the paragraph descriping shows that 91419-48-6 is playing an increasingly important role.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem