With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89895-06-7,1-(Piperidin-4-yl)ethanone hydrochloride,as a common compound, the synthetic route is as follows.,89895-06-7
Step 1 4-acetyl-1-(benzyloxycarbonyl)piperidine STR56 To a stirred solution of 4-acetylpiperidine hydrochloride (22.6 g, 0.138 mol) in saturated aqueous Na2 CO3 (100 mL), cooled to 5 C., was added benzyl chloroformate (23.6 mL, 0.166 mol) dropwise over 10-15 min. The resulting suspension was stirred for 1/2 hour and was filtered. The solid was recrystallized from hexane (200 mL) and ethyl acetate (20 mL) producing 30.5 g of the title compound as a white solid. M.P. 87-89 C.
As the paragraph descriping shows that 89895-06-7 is playing an increasingly important role.
Reference：
Patent; Merck & Co., Inc.; US5792778; (1998); A;,
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