With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885275-00-3,Benzyl 4-iodopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,885275-00-3
A premixed mixture of TMSCl and 1,2-dibromoethane (7:5, v/v,0.80 mL total volume added) was added dropwise over 5 min to asuspension of zinc (1.622 g, 24.8 mmol) in DMA (12 mL) underargon atmosphere. The mixture was stirred for 15 min before benzyl4-iodopiperidine-1-carboxylate19 (7.13 g, 20.7 mmol) wasadded dropwise over 15 min as a solution in DMA (6 mL). This mixturewas stirred for an additional 15 min before adding to quinoxaline71 below.The above (1-((benzyloxy)carbonyl)piperidin-4-yl)zinc(II)iodide (8.49 g, 20.7 mmol) solution was added slowly to a suspensionof 2-chloro-3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxaline71 (5.0 g, 13.8 mmol), copper(I) iodide (0.262 g,1.378 mmol), and Pd(dppf)Cl2 dichloromethane adduct (0.56 g,0.69 mmol) in DMA (15 mL) under argon. This mixture was stirredat 80 C for 2 h, then cooled to room temperature. EtOAcwas added and the suspension was filtered through Celite toremove insoluble material. The filtrate was then diluted withmore EtOAc and then washed with water (3), brine (1), dried(MgSO4), filtered, and concentrated in vacuo to give an oil. Thisoil was purified by silica gel chromatography eluting with0-100% EtOAc/hexane to give 6.93 g (92%) of the title compoundan off-white solid.
As the paragraph descriping shows that 885275-00-3 is playing an increasingly important role.
Reference：
Article; Rzasa, Robert M.; Frohn, Michael J.; Andrews, Kristin L.; Chmait, Samer; Chen, Ning; Clarine, Jeffrey G.; Davis, Carl; Eastwood, Heather A.; Horne, Daniel B.; Hu, Essa; Jones, Adrie D.; Kaller, Matthew R.; Kunz, Roxanne K.; Miller, Silke; Monenschein, Holger; Nguyen, Thomas; Pickrell, Alexander J.; Porter, Amy; Reichelt, Andreas; Zhao, Xiaoning; Treanor, James J.S.; Allen, Jennifer R.; Bioorganic and Medicinal Chemistry; vol. 22; 23; (2014); p. 6570 – 6585;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem