With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873924-08-4,tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate,as a common compound, the synthetic route is as follows.
Tert-butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate (2.15 g, 8.05 mmol) was dissolved in EtOH (20 mL), and thereto was added a methylamine ethanol solution (33% [w / w], 3.7 g, 40.3 mmol), and the reaction solution was stirred at room temperature for 1.5 hours. Then NaBH3CN (1.5 g, 24.2 mmol) was added and after the addition was complete the reaction mixture was stirred at room temperature overnight. After the reaction was completed, the residue was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (DCM / MeOH (v / v) = 10/1) to give the title compound as a yellow oil (1.05 g, 46.2%)., 873924-08-4
As the paragraph descriping shows that 873924-08-4 is playing an increasingly important role.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Hu Haiyang; Wang Tingjin; (91 pag.)CN104672250; (2017); B;,
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