Analyzing the synthesis route of 79421-45-7

79421-45-7 1-(4-Nitrophenyl)piperidin-4-ol 613768, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79421-45-7,1-(4-Nitrophenyl)piperidin-4-ol,as a common compound, the synthetic route is as follows.

79421-45-7, A mixture of the yellowish solid (0.90 g, 4.05 mmol) and Pd-C (10%, 120 mg) in MeOH (20 mL) containing aqueous 6N HCl (0.20 mL) was hydrogenated under balloon H2 overnight. It was filtered through celite. The filtrate was concentrated in vacuo to give a solid (0.841 g) as l-(4-aminophenyl)piperidin-4-ol.

79421-45-7 1-(4-Nitrophenyl)piperidin-4-ol 613768, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem