With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.
In a 100 mL single-necked flask,will4-oxopiperidine-1-Formic acid tert-butyl ester(1.81 g, 9.08 mmol)Was dissolved in CH2Cl2 (42 mL)The ice bath was cooled with stirring,DAST (4.0 mL, 29.4 mmol) was slowly added dropwise to the reaction system,The reaction was stirred at this temperature for 4 h.The reaction was quenched by adding saturated aqueous NaHCO3 (30 mL) to the reaction system,Then extracted with CH2Cl2 (50 mL x 3)The organic phases were combined and washed with saturated NaCl solution (20 mL)Anhydrous Na2SO4 dry,filter,Concentrated under reduced pressure,The crude product was isolated by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 5/1)To give the object as a colorless liquid (1.21 g, 60%).
79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; Guangdong HEC Pharmaceutical Co., Ltd.; Zhong, Xue; Liu, Bing; Xue, Yaping; Li, Xuke; Wang, Feng; He, Wei; Chen, Xiaoyan; Zhang, Yingjun; Zheng, Changchun; (56 pag.)CN106187838; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem