Analyzing the synthesis route of 768-66-1

The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Catalyst [CuCl{2,5-bis(2-thiophenyl)phosphole}2] (1) (2.6 mg, 0.003 mmol, 0.1 mol%), paraformaldehyde (3.0 mmol), amine (3.3 mmol), phenylacetylene (4.5 mmol) and chlorobenezene (1 mL) were loaded in a screw-cap test tube equipped with a stirring bar. The mixture was stirred at 100 C for 5 h, cooled, extracted with ether (3×5 mL) and dried over MgSO4. The mixture was filtrated, concentrated and the residue was purified by flash chromatography on silica gel using a hexane/EtOAc mixture as eluent. The corresponding propargylamines were obtained as yellow oil. Reported yields are the average of at least two independent runs., 768-66-1

The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Cammarata, Jose Ricardo; Rivera, Rocio; Fuentes, Franmerly; Otero, Yomaira; Ocando-Mavarez, Edgar; Arce, Alejandro; Garcia, Juan M.; Tetrahedron Letters; vol. 58; 43; (2017); p. 4078 – 4081;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem