768-66-1,768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 1L four-necked round bottom flask equipped with a mechanical stirrer, a reflux, a thermometer, a funnel and a septum are added 80 g of water, 20 g K2CO3 (99%; 1.44·10-1 mol), 20 g 2,2,6,6-tetramethylpiperidine (99%; 1.41·10-1 mol) and 150 g toluene. Then, a solution of 31.3 g of peracetic acid (35 wt %, Aldrich; 1.44·10-1 mol) in 300 g water is slowly added to the 1L flask while stirring vigorously (with a slightly exothermic reaction) and the flask is placed in a water bath at room temperature. After the addition, the reaction medium is stirred at room temperature overnight, and the organic phase becomes progressively red due to the formation of 2,2,6,6-tetramethylpiperidine-1-oxide (TEMPO). [0108] Then, the stirring is terminated and the water phase is removed from the reaction flask. The red organic phase is then degassed by bubbling argon for 10 minutes. 11.82 g azobisisobutyronitrile (AIBN, 7.2·10-2 mol) are then slowly added by small portions under an argon atmosphere and while stirring vigorously. Then, 100 g of degassed toluene is added rapidly to the reaction flask and the temperature is increased to 60 C. After 24 h at 60 C., the solution is cooled at room temperature. Finally, this organic solution is washed 3 times with water (pH=3) and then, dried with Na2SO4. After drying under vacuum at 50 C., 17.95 g of crude alkoxyamine 1 is collected.
The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Detrembleur, Christophe; Grob, Thomas; Meyer, Rolf-Volker; US2004/2606; (2004); A1;,
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