768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1
2) Experimental Procedures and Analytical DataTypical Procedure 1: Preparation of the reagent TMPZnCl.LICl (2):A dry and argon flushed 250 mL Schlenk-flask, equipped with a magnetic stirrer and a septum, was charged with freshly 2,2,6,6-tetramethylpiperidine (10.22 mL, 60 mmol) dissolved in THF (60 mL). This solution was cooled to -40 C. and n-BuLi (2.4 M in hexane, 25 mL, 60 mmol) was dropwise added. After the addition was complete, the reaction mixture was allowed to warm up slowly to -10 C. for 1 h. ZnCl2 (1.0 M in THF, 66 mL, 66 mmol) was dropwise added and the resulting solution was stirred for 30 min at -10 C. and then for 30 min at 25 C. The solvents were then removed under vacuum affording a yellowish solid. Freshly distilled THF was then slowly added under vigorous stirring until the salts were completely dissolved. The freshly prepared TMPZnCl.LiCl (2) solution was titrated prior to use at 25 C. with benzoic acid using 4-(phenyiazo)diphenylamine as indicator. A concentration of 1.3 M in THF was obtained.Typical Procedure for the Zincation of Polyfunctionalized Aromatics and Heterocycles with TNIPZnCl.-LICl (TP 2):
The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Knochel, Paul; Mosrin, Marc; US2011/288296; (2011); A1;,
Piperidine – Wikipedia
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