With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72551-53-2,Ethyl 1-benzylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.
72551-53-2, General procedure: To a stirred solution of the carboxylate (1.50 g, 7.85 mmol, 1.0eq.) in toluene (25 ml), was added Red-Al (65 wt % in toluene,3.66 g, 3.54 ml, 11.8 mmol, 1.5 eq.) at 15-20 C. The contents were stirred overnight at rt. The reaction was quenched by the slowaddition of 10% sodium hydroxide (~1 ml) and then the addition ofwater. The contents were stirred for 30 min, and the toluene layerwas separated, washed with a saturated solution of sodium chloride.The organic layer was dried (anhydrous sodium sulfate), filtered and evaporated in vacuo to yield the alcohol which was used without any further purification
72551-53-2 Ethyl 1-benzylpiperidine-3-carboxylate 2736370, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; van Greunen, Divan G.; Cordier, Werner; Nell, Margo; van der Westhuyzen, Chris; Steenkamp, Vanessa; Panayides, Jenny-Lee; Riley, Darren L.; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 671 – 690;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem