71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,71985-80-3
Example 252; 1 -Methyl-piperidine-4-carboxylic acid ((S)-I -{2-[6-cyano-3-(4-methoxy- benzenesulfonyl)-2-oxo-2,3-dihydro-benzoimidazol-1 -yl]-2 -phenyl -acetyl}- pyrrolidin-3-yl)-amide; compound with trifluoroacetic acid; A mixture of i-methylpiperidine-4-carboxylic acid hydrochloride (16 mg, 0.09 mmol), 1-hydroxybenzotriazole (15 mg, 0.11 mmol) and PS-carbodiimide resin (Argonaut; 1.25 mmol/g; 72 mg, 0.09 mmol) in CH2CI2 (3 ml.) was agitated for 10 min at room temperature. Then, 3-[2-((S)-3-amino-pyrrolidin-1 -yl)-2-oxo-1 -phenyl-ethyl]-1 -(4- methoxy-benzenesulfonyl)-2-oxo-2,3-dihydro-1 H-benzoimidazole-5-carbonitrile (40 mg, 0.08 mmol) was added and the reaction mixture was agitated at room temperature overnight. To this was then added MP-carbonate resin (Argonaut; 3.08 mmol/g; 73 mg, 0.23 mmol) and the reaction mixture was agitated for another 2 hours, filtered and concentrated in vacuo. The residue was purified by preparative RP-HPLC (eluent: gradient from 10% to 80% acetonitrile in water, 0.1% trifluoroacetic acid as modulator) to afford 1 -methyl-piperidine-4-carboxylic acid ((S)- 1-{2-[6-cyano-3-(4-methoxy-benzenesulfonyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]- 2-phenyl-acetyl}-pyrrolidin-3-yl)-amide; compound with trifluoroacetic acid (13 mg, 21%) as a white solid.1H-NMR (500 MHz, DMSOd6): delta 1.61-2.04 (m, 5H), 2.15-2.33 (m, 1 H), 2.77 (m, 3H), 2.90 (m, 2H), 3.11 (m, 1 H), 3.27 (m, 1 H), 3.42-3.98 (m, 6H), 3.87 (s, 3H), 6.32-6.42 (m, 1 H), 6.97-7.10 (m, 1 H), 7.20 (dd, 9.1 Hz, 2.4 Hz, 2H), 7.22-7.30 (m, 2H), 7.39 (m, 3H), 7.61-7.65 (m, 1 H), 7.97 (dd, 8.5 Hz, 4.7 Hz, 1 H), 7.99-8.03 (m, 2H). MS (API-ES, pos) m/z = 657.20 [M+H]+.
As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.
Reference：
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
Piperidine – Wikipedia
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