683233-14-9, (R)-tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of(1S,3?R,6?R,7?R,8?E,11?S,12?R)-6-chloro-7?-methoxy- 11?, 1 2?-dimethyl-l 5? -oxo-3,4-dihydro-2H-spiro [naphthalene- 1,22? – [20joxa[13jthia[1,14jdiazatetracyclo[14.7.2.03,6.019,24jpentacosa[8,16,18,2 4jtetraenej-7?-carbaldehyde 13?,13?-dioxide (44 mg, 0.069 mmol) in 1,2-dichloroethane (1 mL) was added (R)-tert-butyl 2-(aminomethyl)piperidine-1- carboxylate (147 mg, 0.686 mmol). The resulting mixture was then stirred at room temperature for 1 h. Then, sodium triacetoxyborohydride (73 mg, 0.343 mmol) was added in portions. After addition, the mixture was then stirred at room temperature for 3 d. The mixture was purified by silica gel columnchromatography (0% to 20% MeOH/DCM) to provide 2-methyl-2-propanyl (2R)-2-(((((1S,3?R,6?R,7?R,8?E,1 1?S,12?R)-6-chloro-7?-methoxy-11?,12?-dimethyl-13?, 13? -dioxido- 15 ?-oxo-3,4-dihydro-2H-spiro[naphthalene- 1,22? -[20joxa[13jthia[1,14jdiazatetracyclo[14.7.2.03,6.019,24jpentacosa[8,16,18,24jtetraenj -7? -yl)methyl)amino)methyl)- 1 -piperidinecarboxylate (57.6 mg, 0.069mmol, 100 % yield) as a light yellow solid, which was used in the next step. MS (ESI, +ve ion) m/z 839.4 (M+H).
683233-14-9, As the paragraph descriping shows that 683233-14-9 is playing an increasingly important role.
Reference：
Patent; AMGEN INC.; HARRINGTON, Paul E.; ASHTON, Kate; BROWN, Sean P.; KALLER, Matthew R.; KOHN, Todd J.; LANMAN, Brian Alan; LI, Kexue; LI, Yunxiao; LOW, Jonathan D.; MINATTI, Ana Elena; PICKRELL, Alexander J.; STEC, Markian M.; TAYGERLY, Joshua; (991 pag.)WO2018/183418; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem