6457-49-4 4-Piperidinemethanol 420771, apiperidines compound, is more and more widely used in various fields.
6457-49-4, 4-Piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6457-49-4, 1.1 Synthesis of ^Hydroxymethyl-piperidine-i-carboxylic tert-butyl ester 1Og of 4-piperidine methanol was dissolved in 10OmIs of dichloromethane and the solution treated with 14.5mls of triethylamine under nitrogen. The mixture was cooled to O0C using an ice bath and stirred. 19g of boc anhydride was added portionwise to the mixture over 15 minutes. The reaction mixture was then stirred overnight allowing the whole to warm to RT. The reaction mixture was diluted with a further 30OmIs dichloromethane and washed with 1 N HCI(aq) (250ml) followed by a wash with brine before drying over anhydrous magnesium sulphate. The dried organics were filtered and evaporated to dryness to give 17.8g of colourless crystalline solid.1H-NMR (400MHz, CD3OD) OH 4.88(2H s) 4.08(1 H d), 3.39(1 H d), 1.70(1 H d), 1.60(1 H m), 1.44(9H s), 1.08(2H m)
6457-49-4 4-Piperidinemethanol 420771, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; VERNALIS (R & D) LIMITED; WO2008/38011; (2008); A1;,
Piperidine – Wikipedia
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