336191-17-4, tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of compound 24 (300.00 mg, 1.25 mmol, 1.00 eq.) and benzoic acid (183.18 mg, 1.50 mmol, 1.20 eq.) in DCM (6 mL) was added NMM (252.88 mg, 2.50 mmol, 2.00 eq.) and T3P (1.19 g, 1.88 mmol, 1.50 eq.). The mixture was stirred at 25 C for 4 hrs.Then the mixture was purified by TLC (PE:EtOAc=1:1) to compound 25 (310.00 mg, 899.99 umol, 72.00% yield). To a solution of compound 25 (310.00 mg, 899.99 umol, 1.00 eq.) in DCM (2 mL) was added HCl/AcOEt (30mL) at 0 C. The mixture was stirred at 25 C for 2 hrs. Then it was concentrated to dryness to give compound 26 (300.00 mg, crude). To a solution of compound 6 (20.00 mg, 66.39 umol, 1.00 eq.) and compound 26 (19.47 mg, 79.67 umol, 1.20 eq.) in pyridine (3.00 mL) was added EDCI (19.09 mg, 99.59 umol, 1.50 eq.) at 25 C , the mixture was stirred for 3 h our at 25 C. LCMS showed the SM consumed, desired product was formed as major product. The reaction was concentrated, dissolved in to DMF (3 mL), purified by prep-HPLC (base condition) and concentrated to give SC27 (11.00 mg, 20.37 umol,30.68% yield, 97.7% purity) as yellow gum.
336191-17-4, As the paragraph descriping shows that 336191-17-4 is playing an increasingly important role.
Reference£º
Article; Tuyishime, Marina; Lawrence, Rae; Cocklin, Simon; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 228 – 234;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem