With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2905-56-8,1-Benzylpiperidine,as a common compound, the synthetic route is as follows.
General procedure: To a suspension of 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate (1, 0.975 mmol) in MeCN(3 mL) the amine (2, 0.75 mmol) dissolved in MeCN (3 mL) was added dropwise at r.t. The reaction was stirred at r.t. for another20 min. The solvent was evaporated, and the obtained residuewas purified via flash column chromatography using silica gel as stationary phase. Benzaldehyde (5a) 1H NMR (400 MHz, CDCl3): delta = 10.05 (s, 1 H), 7.89?7.95 (m, 2 H),7.63?7.69 (m, 1 H), 7.54?7.60 (m, 2 H) ppm. 13C NMR (101 MHz,CDCl3): delta = 192.4, 136.5, 134.5, 129.8, 129.0 ppm. IR: nu = 3070(m), 2837 (m), 2678 (w), 1559 (w), 1686 (vs) cm?1., 2905-56-8
2905-56-8 1-Benzylpiperidine 76190, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Hauser, Anett; Bohlmann, Rolf; Synlett; vol. 27; 12; (2016); p. 1870 – 1872;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem