With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287952-67-4,4-(4-Trifluoromethoxyphenoxy)piperidine,as a common compound, the synthetic route is as follows.
Example 25; Production of (5) -4- [4- (trifluoromethoxy) phenoxy] -l-{ 4- [ (2, 2, 4- trimethyl-1, 3-dioxolane-4-ly) methoxy] phenyl }piperidine; (S) -4- (4-Bromophenoxy)methyl-2, 2, 4-trimethyl-l, 3- dioxolane (2.32 g, 7.7 mmol), 4- [4-(trifluoromethoxy) phenoxy] piperidine (2.0 g, 7.7 mmol),tris (dibenzylideneacetone) dipalladium (0) (0.141 g, 0.15 mmol), 2- dicyclohexylphosphino-2′ – (N, N-dimethylamino) biphenyl (0.145 g, 0.37 mmol), potassium hydroxide (0.864 g, 15.4 mmol),tributylamine (5 mL) , and xylene (46 ml) were mixed, followed by stirring under a nitrogen atmosphere at 80 C for 8 hours. Using HPLC, it was confirmed that (S) -4- [4- (trifluoromethoxy) phenoxy] – l-{4- [ (2,2, 4-trimethyl-l, 3-dioxolane-4- ly) methoxy] phenyl }piperidine was produced with the inversion rate of 99%., 287952-67-4
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Reference£º
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; YAMAMOTO, Akihiro; SHINHAMA, Koichi; FUJITA, Nobuhisa; AKI, Shinji; OGASAWARA, Shin; UTSUMI, Naoto; WO2011/93529; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem