19099-93-5, 1-Cbz-Piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
At 0C, to a solution of benzyl 4-oxopiperidine-1-carboxylate (2.00 g, 8.57 mmol, 1.00 equivalent) in tetrahydrofuran(25 mL) were added sodium hydride (719.88 mg, 18.00 mmol, 2.10 equivalents) and potassium iodide (3.80g, 26.74 mmol, 3.12 equivalents) in one portion. The mixture was stirred at 30C for 16 hours. LC/MS showed completionof the reaction. The reaction mixture was added a solution of ammonium chloride (50 mL) thereto and then subjectedto extraction using ethyl acetate (50 mL32). The organic phase was concentrated and dried. The obtained residue waspurified by preparative TLC plate (petroleum ether: ethyl acetate = 6: 1) to give the title compound (870.00 mg, 3.33mmol, 38.86% yield) as a transparent oil. 1H NMR (400 MHz, Methanol-d4) delta 7.38-7.33 (m, 5H), 5.19 (s, 2H), 3.81-3.77(t, J = 6.4 Hz, 2H), 3.50-3.46 (m, 2H), 2.50 (s, 2H), 1.11-1.04 (m, 6H). LC/MS (ESI) m/z: 284.1 (M+1).
19099-93-5, The synthetic route of 19099-93-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; DING, Charles Z.; CHEN, Shuhui; ZHAO, Baoping; XU, Zhaobing; LIU, Yingchun; LIN, Ruibin; WANG, Fei; LI, Jian; (101 pag.)EP3269715; (2018); A1;,
Piperidine – Wikipedia
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