With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15883-20-2,N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide,as a common compound, the synthetic route is as follows.
To 1L four reaction flask was added 500g of toluene, then add 100g of starting material,Then add 1.01 ~ 1.05 equivalent of anhydrous potassium carbonate, then add 2% to 6% tetrabutylammonium bromide,Then add 1.1 to 1.3 times the equivalent of n-butyl bromide, and slowly warmed to 80 ~ 85 , incubated for 5 hours,Cooled to room temperature, filtered, the filtrate was transferred to a 1L four-necked flask,Hydrogen chloride gas is passed into the filtrate until it is no longer absorbed, filtered, the filter cake washed with toluene,Dried to give bupivacaine hydrochloride 132.84 ~ 141.70g,HPLC content> 99%, yield 90% ~ 96%., 15883-20-2
The synthetic route of 15883-20-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Jiangsu Tianhe Pharmaceutical Co., Ltd.; Wang Lei; Liu Lei; Zhao Yunde; Wang Zhiquan; Zhu Linfei; (9 pag.)CN106117118; (2016); A;,
Piperidine – Wikipedia
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