156185-63-6, tert-Butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example D2: 1-Methylcyclopropyl 4-(3-(6-(methylsulfonyl)-5,6,7,8- tetrahydropyrido[4,3-J]pyrimidin-2-yloxy)propyl)piperidine-l-carboxylate. ; Step A: To a stirred solution of tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate (40.6 g, 167 mmol) and pyridine (27 rnL, 184 mmol) in DCM (150 rnL) is slowly added MsCl (14.3 rnL, 184 mmol) over 30 min at 0C. The reaction is then stirred at 0C for 1 h and then at rt overnight. The reaction mixture is partitioned between water (50 mL) and EtOAc (100 mL). The aqueous layer is separated and is further extracted with EtOAc (2×100 mL). The organics are combined and washed with brine (25 mL), dried (MgSO4), and evaporated to give an amber-colored oil. The crude is purified by flash chromatography (SiO2, EtOAc/hexanes gradient) to give tert-butyl 4- (3-(methylsulfonyloxy)propyl)piperidine-l-carboxylate 22 as a light yellow oil: 1H NMR (400 MHz, CD3CN) delta 4.18 (t, J = 4.8 Hz, 2H), 4.00 (m, 2H), 2.99 (s, 3H), 2.67 (m, 2H), 1.72 (m, 2H), 1.65 (m, 2H), 1.43 (m, IH), 1.41 (s, 9H), 1.30 (m, 2H), 1.01 (ddd, J = 3.3, 9.6, 18.6 Hz, 2H); MS calcd. for C9H20NO3S [M-Boc+H]+: 222.1, found: 221.9.
156185-63-6, 156185-63-6 tert-Butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate 2800739, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; IRM LLC; WO2009/105717; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem