The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.
1454-53-1, Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1454-53-1, Preparation of 1-benzyl-4-trifluorornethanesulfonyloxy-1 , 2,5,6- tetrahvdro-rhoyridine-3-carboxylic acid ethyl ester; A solution of 15% sodium carbonate (6L) was prepared and to this was added ethyl N-benzyl-3-oxo-piperidine carbalphaxylate hydrochloride (1800 g, 6.06 mol). The slurry was allowed to stir for one hour at which time most of the solids had dissolved. To this was added MTBE (6L). The organic layer was removed and the aqueous layer was extracted twice more with MTBE (2 L each extraction). The combined organic layers were dried over sodium sulfate, filtered, and the solvent was removed by rotary evaporation giving an orange oil (1422 g, 90%). The oil was used without any further purification, To a room temperature suspension of sodium hydride (120 g, 3.0 mol) in diethyl ether (9 L) was added the free ethyl N-benzyl-3-oxo-piperidine carboxylate (711 g, 2.72 mol) as a solution in diethyl ether (1 L). Once the addition was complete the reaction mixture was allowed to stir at room temperature for one hour. Trifluoromethanesulfonic anhydride (460 mL, 2.72 mol) was then added carefully and the reaction mixture was allowed to stir overnight. The reaction was quenched with saturated ammonium chloride and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, and the solvent was removed by rotary evaporation giving 1-benzyl-4-trifluoromethanesulfonyloxy-1 ,2,5,6-tetrahydro- pyridine-3-carboxylic acid ethyl ester as an orange oil (940 g, 88%). The crude product was used without any further purification.
The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER INC.; WO2008/120093; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem