With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141699-59-4,tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
NaH (1.2 eq., 0.68 mmol) was added portionwise to a stirred solution of 4-iodopyrazole (0.57 mmol) in DMF (2 L) at 4C. The resulting mixture was stirred for 1 hour at 4C and compound 23-4 (1.1 eq., 0.63 mmol) was then added. The resulting mixture was heated to 100C for 12 h. The reaction was quenched with H2O and extracted with EtOAc several times. The combined organic layers were dried, filtered, and concentrated to afford an orange oil. The residue was purified by silica gel chromatography (eluting with 5% EtOAc in pentane) to give compound 23-1 a as a white solid (140 g, 66%).
As the paragraph descriping shows that 141699-59-4 is playing an increasingly important role.
Reference£º
Patent; PFIZER INC.; WO2006/21881; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem