13625-39-3, 1,3,8-Triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2-1 10-(oxiran-2-ylmcthyl)-2-(trifluoromcthyl)- 10//-phcnothiazinc (100 mg, 0.31 mmol) and K2CO3 (214 mg, 1.55 mmol) in DMF (10 mL) was added 1,3,8- triazaspiro[4.5]decane-2,4-dione (210 mg, 1.24 mmol), and the reaction mixture was stirred at 80 C overnight. Then the mixture was concentrated to dryness. The residue was purified by prep- HPLC (Waters XBridge C18 (50 mm x 4.6 mm, 3.5 pm); A = H2O (0.01 mol/L NH4HCO3) and B = CH3CN; 15-95% B over 8 min) to afford a white solid (41 mg, 27% yield). MT-03 la NMR (400 MHz, . -DMSO) d ppm 8.69 (s, 1H), 7.36-7.34 (d, J= 7.6Hz, 1H), 7.28-7.17 (m, 4H), 7.05-6.98 (m, 2H), 5.26-5.25(d, J= 6.0 Hz, 1H), 4.12-4.10 (m, 1H), 3.97-3.92(m, 2H), 3.45-3.43(m, J= 6.4 Hz , 2H), 2.84-2.64 (m, 4H), 1.95 (s, 1H), 1.67-1.63 (m, 2H); 1.40-1.32 (m, 2H); LC-MS: Rt = 1.63 min; ESI m/z 493 [M+lf.
13625-39-3, As the paragraph descriping shows that 13625-39-3 is playing an increasingly important role.
Reference£º
Patent; CAMP4 THERAPEUTICS CORPORATION; BUMCROT, David, A.; SEHGAL, Alfica; HERTZOG, Donald L.; (172 pag.)WO2019/195789; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem