118133-15-6, 1-(Ethoxycarbonyl)piperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example-3 Preparation of [1-(2-phenylethyl)-1H-imidazole-2-ylj(piperidin-4-yl)methanonedihydrobromideTo (51.12 grn) of the compound obtained in example-I, toluene (25 ml) and DMF (1.53 ml) was added, followed by the slow addition of thionyl chloride (45.39 grn). The reaction mixture was then heated to 50-55 C and maintained for 2 hours at the same temperature. After completion of the reaction, the excess of thionyl chloride and toluene from the reaction mixture was distilled undervacuum below 70C. The residue obtained was cooled to 5-10C under N2 atmosphere. To the cooled residue, a solution of compound obtained in exarnple-2 (25gm) in acetonitrile (125ml) was slowly added at 0-20C under N2 atmosphere followed by the slow addition of triethylamine (29.36gm) at 0-20C for 2 hours and maintained for 3 hrs at the same temperature. The progress of the reaction was monitored by HPLC. After the completion of the reaction, (125rnl) purified waterand (75 ml) ethyl acetate was added to the reaction mixture and stirred for 10 minutes. The organic layer was separated, washed with water and concentrated the organic layer at mass temperature below 55C under vacuum to get a residue. The residue was cooled to 25-30C and (249.57gm) aqueous HBr was added to the residue. The contents were stirred for 10 miii; then heated to 85- 90C and maintained for 12 hrs at the same temperature. The reaction mass was cooled to 55-60Cand (167.5 ml). Isopropyl alcohol was added to the cooled reaction mass, then heated to 65-70C and maintain for 1 hr at the same temperature. The reaction mass was filtered and dried the material in hot air oven at 60-65C for 8 hrs.Percentage Yield: 90%, 118133-15-6
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Reference：
Patent; NEULAND LABORATORIES LIMITED; PONNAIAH, Ravi; HASHMI, Arshad Moosa; NEELA, Praveen Kumar; SEEMALA, Dhanunjaya Naidu; MOKKA, Raviteja; LAHOTI, Anandkumar Madanlal; DEEPTHI, V., P., S., S; SARADHI, G., Srinivas Pardha; WO2014/83571; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem