With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To solution of 4-((3-hydroxypiperidin-1-yl)methyl)benzohydrazide(9, 0.5 g, 2 mmol) in ethanol with catalytic amount of HClwas added the corresponding aldehyde (10, 2.4 mmol). The mixturewas stirred for 3 h at room temperature. Removal of the solventproduced a residue, which was purified using chromatographycolumn with the appropriate eluents systems.
10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Dias Viegas, Flavia Pereira; de Freitas Silva, Matheus; Divino da Rocha, Miguel; Castelli, Maisa Rosa; Riquiel, Mariana Maximo; Machado, Rafael Pereira; Vaz, Sarah Macedo; Simoes de Lima, Lais Medeiros; Mancini, Karla Cristine; Marques de Oliveira, Patricia Cruz; Morais, Elida Parreira; Gontijo, Vanessa Silva; da Silva, Fernanda Motta R.; D’Alincourt da Fonseca Pecanha, Dora; Castro, Newton Goncalves; Neves, Gilda A.; Giusti-Paiva, Alexandre; Vilela, Fabiana Cardoso; Orlandi, Lidiane; Camps, Ihosvany; Veloso, Marcia Paranho; Leomil Coelho, Luis Felipe; Ionta, Marisa; Ferreira-Silva, Guilherme Alvaro; Pereira, Rodrigo Machado; Dardenne, Laurent E.; Guedes, Isabella Alvim; de Oliveira Carneiro Junior, Wellerson; Quaglio Bellozi, Paula Maria; Pinheiro de Oliveira, Antonio Carlos; Ferreira, Fabio Furlan; Pruccoli, Letizia; Tarozzi, Andrea; Viegas, Claudio; European Journal of Medicinal Chemistry; vol. 147; (2018); p. 48 – 65;,
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