With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.
5L reaction flask to dry slowly purged with nitrogen, will 233.3g1-benzyl-4-piperidine carboxylic acid methyl ester (1mol) and 240ml of toluene into a reactor, with stirring, cooled until the internal temperature at about -5 . The resulting red aluminum – morpholine complex (approximately 2.6mol) was dropped to control the reaction temperature between -5 ~ 0 . 3h addition was complete, the reaction was continued insulation 2h. Was added slowly prepared 4N sodium hydroxide solution (containing 360gNaOH), control the internal temperature not higher than 20 , the addition was completed, stirring was stopped, the organic layer was washed with water (1500ml / times, 4 times), the organic layer was concentrated at 75 concentrated under reduced pressure until no solvent was evaporated to give 1-benzyl-4-piperidinemethanol 201.6g, as a pale yellow oily liquid. Yield: 98.2%. HPLC: 99.30%
10315-06-7, As the paragraph descriping shows that 10315-06-7 is playing an increasingly important role.
Reference：
Patent; Shanghai Goldentree Resin Powder Co., Ltd.; Zhu, Ben; (8 pag.)CN105693596; (2016); A;,
Piperidine – Wikipedia
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