I found the field of Pharmacology & Pharmacy very interesting. Saw the article Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility published in 2021. Computed Properties of C7H13NO2, Reprint Addresses Lam, YL (corresponding author), Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore.; Go, ML (corresponding author), Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.
Welcome to talk about 177-11-7, If you have any questions, you can contact Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL or send Email.. Computed Properties of C7H13NO2
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem